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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Immunol. 2013 Jan 4;190(3):961–969. doi: 10.4049/jimmunol.1201362

Figure 5. Selective expression of li-CTLA-4 partially rescues the T cell phenotype observed in NOD.BDC2.5.CTLA-4KO mice.

Figure 5

Relative levels of fl- and li-CTLA-4 mRNA expression in CD4+ T cells (A) and lymph node cellularity (B) in 6 week old NOD.BDC2.5.CTLA-4 WT, KO, KO-Tg or KO-Tg-Cre mice. (C) Representative flow plots, showing the frequencies of activated CD4+/CD44+/CD62L- T effector and resting CD4+/CD44-/CD62Lhi naïve T cells (upper panel) as well as CD4+/CD25+/FoxP3+ regulatory T cells (lower panel) in lymph node cells from 6 week old mice. (D) Quantification of frequencies of CD44+ T effector and FoxP3+ regulatory T cells determined in (C) and expressed as percentage of CD4+ T cells. Statistical analyses were performed using an unpaired t test (*, P < 0.05; **, P < 0.01; ***, P < 0.0001).