Table 3.
Transcriptomic response of Y. lipolytica transporters to sulfur supplya
| S. cerevisiae gene name | Y. lipolytica gene name | Ratio Met | P value for Met | Ratio Cys | P value for Cys | Ratio Sul | P value for sulfate | Function |
|---|---|---|---|---|---|---|---|---|
| SUL1-SUL2 | YALI0B17930g | 0.01 | 1.39E−12 | 0.09 | 0 | 0.16 | 0 | High-affinity sulfate permease |
| SSU1 | YALI0E24167g | 5.23 | 2.83E−12 | Sulfite pump, required for efficient sulfite efflux | ||||
| MUP1 | YALI0F25795g | 0.05 | 1.39E−12 | 0.20 | 1.13E−11 | 0.27 | 8.71E−08 | High-affinity methionine permease |
| YALI0D16137g | 0.02 | 0 | 0.03 | 0 | 0.04 | 0 | ||
| YALI0F03498g | 0.46 | 4.74E−02 | 0.37 | 1.54E−03 | ||||
| YALI0D19646g | 0.32 | 2.22E−07 | ||||||
| YALI0F07018g | ||||||||
| TPO1 | YALI0F07062g | 0.43 | 1.61E−03 | Polyamine transporter | ||||
| YALI0A15576g | ||||||||
| YALI0F08063g | ||||||||
| YALI0E21241g | ||||||||
| YALI0A18902g | ||||||||
| DUR3 | YALI0E28622g | 0.03 | 1.39E−12 | 0.03 | 0 | 0.06 | 0 | Transporter for both urea and polyamines |
| YALI0E33583g | 0.02 | 0 | 0.04 | 1.41E−12 | 0.06 | 0 | ||
| YALI0B04202g | ||||||||
| YALI0C15807g | ||||||||
| GAP1 | YALI0F19866g | 6.55 | 2.78E−12 | 3.93 | 1.02E−08 | 2.32 | 4.08E−03 | General amino acid permease |
| YALI0B19800g | 0.44 | 8.69E−04 | ||||||
| YALI0B16522g | ||||||||
| YALI0C17237g | ||||||||
| YALI0E10219g | ||||||||
| YALI0C09889g | ||||||||
| YALI0B19492g | ||||||||
| OPT2 | YALI0F09691g | 0.11 | 0 | 0.20 | 7.07E−12 | 0.35 | 3.96E−04 | Oligopeptide transporter |
| YALI0A00110g | 0.29 | 1.35E−09 | ||||||
| YALI0C18491g | ||||||||
| YALI0B07898g | ||||||||
| YALI0C20823g | ||||||||
| YALI0F30041g | ||||||||
| YALI0F18964g | ||||||||
| YALI0B04642g | ||||||||
| YALI0F13959g | ||||||||
| YALI0A03949g | ||||||||
| YALI0E19294g | ||||||||
| YALI0B02090g | ||||||||
| YALI0E17589g | ||||||||
| YALI0F10241g | ||||||||
| YALI0B02398g | ||||||||
| YALI0C22616g | ||||||||
| JEN1 | YALI0C15488g | 26.58 | 1.39E−12 | 5.43 | 0 | 3.61 | 2.35E−07 | Lactate transporter, required for uptake of lactate and pyruvate |
| YALI0D20108g | ||||||||
| YALI0D24607g | ||||||||
| YALI0E32901g | ||||||||
| YALI0C21406g | ||||||||
| YALI0B19470g | ||||||||
| SEO1 | YALI0C17281g | 0.14 | 0 | 0.10 | 0 | 0.14 | 0 | Putative allantoate permease |
| YALI0C17303g | 0.06 | 0 | 0.03 | 0 | 0.04 | 0 | ||
| YALI0F13607g | 0.05 | 0 | 0.22 | 1.55E−11 | 0.17 | 0 | ||
| YALI0E35200g | 0.33 | 2.28E−07 | ||||||
| YALI0C00627g | ||||||||
| YALI0B01904g | ||||||||
| YIL166c | YALI0D00407g | 0.01 | 0 | 0.03 | 1.41E−12 | 0.03 | 0 | Similarity to allantoate permease |
| YALI0B16412g | 0.36 | 1.71E−04 | 0.44 | 1.49E−02 | 0.34 | 1.81E−04 |
a
Values described in the text (P values of ≤0.05 and ratios of ≤0.5 or ≥2) are listed in this table. Ratio Met, ratio of high to low methionine results; Ratio Cys, ratio of high to low cystine results; and Ratio Sul, ratio of high to low sulfate results.