Table 6.
Metabolomic response of Y. lipolytica to sulfur supplya
| Compound | Area |
Ratio |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| HM | LM | HC | LC | HS | LS | Met | Cys | Sul | |
| 5-Methylthioadenosine | 1.30E+09 [1.19, 1.37]E+09 | 3.92E+08 [3.38, 4.72]E+08 | 4.04E+07 [3.32, 4.94]E+07 | 2.54E+08 [1.85, 2.92]E+08 | 9.54E+07 [8.24, 10.70]E+07 | 3.40E+08 [2.60, 4.13]E+08 | 3.32 | 0.16 | 0.28 |
| Cystathionine | 1.74E+08 [1.48, 2.24]E+08 | 1.64E+07 [1.21, 1.88]E+07 | 1.93E+06 [1.45, 2.80]E+06 | 8.87E+06 [4.72, 12.70]E+06 | 5.75E+06 [5.07, 6.71]E+06 | 1.01E+07 [0.92, 1.13]E+07 | 10.67 | 0.22 | 0.57 |
| Hypotaurine | 2.89E+07 [2.53, 3.55]E+07 | 1.45E+06 [1.39, 1.55]E+07 | 2.68E+06 [2.22, 3.21]E+06 | 9.03E+05 [6.29, 11.70]E+05 | 1.76E+06 [0.97, 2.22]E+06 | 1.16E+06 [0.05, 2.12]E+06 | 19.91 | 2.97 | |
| Spermidine | 4.37E+08 [4.30, 4.49]E+08 | 3.56E+08 [3.13, 4.06]E+08 | 2.34E+08 [2.29, 2.39]E+08 | 2.70E+08 [2.43, 3.04]E+08 | 3.68E+08 [3.19, 4.03]E+08 | 3.75E+08 [3.36, 4.14]E+08 | 1.23 | 0.87 | |
| Taurine | 8.72E+06 [7.66, 9.70]E+06 | 1.98E+06 [1.80, 2.07]E+06 | 2.65E+06 [2.47, 2.81]E+06 | 1.11E+06 [0.83, 1.28]E+06 | 3.15E+06 [2.29, 4.04]E+06 | 1.50E+06 [0.46, 3.47]E+06 | 4.41 | 2.39 | |
| Cysteine | 1.23E+07 [1.11, 1.33]E+07 | 6.36E+06 [6.03, 6.70]E+06 | 5.82E+06 [5.26, 6.28]E+06 | 4.89E+06 [3.87, 5.81]E+06 | 1.58E+05 [0.76, 2.49]E+05 | 4.35E+06 [3.00, 5.24]E+06 | 1.94 | 0.04 | |
| γ-Glutamylcysteine | 4.24E+06 [3.49, 5.08]E+06 | 6.96E+06 [6.80, 7.23]E+06 | 5.17E+06 [4.63, 6.26]E+06 | 5.01E+06 [3.40, 5.87]E+06 | 8.36E+05 [5.50, 12.50]E+05 | 7.44E+06 [5.05, 11.80]E+06 | 0.61 | 0.11 | |
| Methionine | 1.21E+08 [0.94, 1.94]E+08 | 1.79E+07 [1.76, 1.82]E+07 | 9.13E+06 [8.43, 9.76]E+06 | 1.22E+07 [0.83, 1.48]E+07 | 1.78E+07 [1.37, 2.13]E+07 | 1.80E+07 [1.38, 2.54]E+07 | 6.75 | ||
| Serine | 2.03E+07 [1.86, 2.31]E+07 | 5.53E+07 [5.39, 5.79]E+07 | 4.08E+07 [3.57, 4.97]E+07 | 3.63E+07 [2.64, 4.45]E+07 | 4.86E+07 [3.62, 5.72]E+07 | 5.29E+07 [4.77, 5.74]E+07 | 0.37 | ||
| Glutathione | 4.67E+08 [4.18, 5.43]E+08 | 5.03E+08 [4.73, 5.53]E+08 | 4.55E+08 [4.01, 5.50]E+08 | 3.81E+08 [2.96, 4.25]E+08 | 2.22E+08 [2.00, 2.52]E+08 | 5.05E+08 [4.31, 6.50]E+08 | 0.44 | ||
| Cysteinylglycine | 5.82E+07 [5.16, 6.73]E+07 | 6.45E+07 [5.79, 7.43]E+07 | 5.96E+07 [5.31, 7.10]E+07 | 5.01E+07 [4.23, 5.46]E+07 | 3.32E+06 [2.31, 3.96]E+06 | 6.01E+07 [4.87, 7.60]E+07 | 0.06 | ||
| O-Acetylhomoserine | 9.43E+04 [3.27, 12.90]E+04 | 9.20E+04 [4.82, 11.73]E+04 | 4.67E+04 [1.77, 8.77]E+04 | 4.70E+04 [3.40, 6.44]E+04 | 2.99 + 04 [0.76, 4.48]E+04 | 1.68E+04 [4.29, 14.59]E+04 | |||
a
H, high; L, low; M, methionine; C, cystine; S, sulfate; Ratio Met, HM/LM ratio; Ratio Cys, HC/LC ratio; Ratio Sul, HS/LS ratio. The areas indicated are means for three independent experiments. Extreme values are indicated in brackets.