. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: Future Cardiol. 2013 Jan;9(1):89–103. doi: 10.2217/fca.12.71

Table 1.

Cysteinyl cathepsins in different pathological events from experimental abdominal aortic aneurysms.

Pathological event	Cathepsins
Lesion leukocyte recruitment (e.g., macrophage, T cell and neutrophil)	CatS, CatL, CatK, CatC^†
Lesion inflammatory cell proliferation (e.g., T cells)	CatS, CatL, CatK
EC and SMC cathepsin and MMP expression or activity	CatL, CatK
Lesion CatK and MMP-2/9 expression and activity	CatS
Lesion CatS/K activity and expression	CatL, CatK
Lesion elastin and collagen degradation	CatS, CatL, CatK
Lesion SMC apoptosis and loss	CatS, CatK (not CatL)
Other lesion cell apoptosis	CatS, CatK (not CatL)
Angiogenesis	CatS, CatL (not CatK)

^†

CatC activities on other listed events were not tested.

EC: Endothelial cell; MMP: Matrix metalloproteinase; SMC: Smooth-muscle cell.