Table 2.

Role of matrix metalloproteinases and tissue inhibitors of metalloproteinases in different experimental abdominal aortic aneurysm models.

Proteases/inhibitors	AAA models	Animals	Observations	Ref.
Mmp2−/−	Peri-aortic CaCl2 injury	Mice	Reduced AAA	[98]
Mmp9−/−	Peri-aortic CaCl2 injury	Mice	Reduced AAA	[98]
Mmp9−/−	Elastase perfusion	Mice	Reduced AAA	[96]
Mmp12−/−	Elastase perfusion	Mice	No effect†	[96]
MT1-MMP−/−	Bone marrow transplantation followed by CaCl2 injury	Mice	Reduced AAA	[99]
Timp1−/−Apoe−/−	High-cholesterol diet	Mice	Increased AAA	[100]
Timp1−/−	Elastase perfusion	Mice	Increased AAA	[101]
TIMP-2	Local overexpression followed by elastase perfusion	Rat	Reduced AAA	[102]
Timp2−/−	Peri-aortic CaCl2 injury	Mice	Reduced AAA†	[103]

^†Study with unexpected results.

AAA: Abdominal aortic aneurysm.