Table 3.

Direct and indirect matrix metalloproteinase inhibitors in reducing experimental abdominal aortic aneurysms.

Inhibitors	AAA models	Animals	Additional observations	Ref.
BB-94 (batimastat)	Elastase perfusion	Rats	Reduced lesion inflammation and increased elastin preservation	[106]
Doxycycline	Elastase perfusion	Mice	–	[96]
Doxycycline	Thioglycolate-plasmin perfusion	Rats	Reduced lesion MMP-9 activity and elastin degradation, no effect on MMP-2 activity	[108]
Doxycycline	Elastase perfusion	Rats	Reduced lesion MMP-9 activity and elastin degradation, no effect on MMP-2 activity	[109]
Doxycycline	Ang II infusion	Mice	No effect on systolic pressure or serum lipid profiles	[110]
Simvastatin	Ang II infusion	Mice	Reduced lesion MMP-2 and -9 activities, inflammation and neovascularization	[119]
Simvastatin	Elastase perfusion	Rats	Reduced lesion MMP-9 levels, ECM expression and oxidative stress	[120]
Simvastatin	Elastase perfusion	Mice	Reduced lesion MMP-9, increased lesion TIMP-1 expression, and reduced media SMC loss and elastin degradation	[121]

AAA: Abdominal aortic aneurysm; ECM: Extracellular matrix; SMC: Smooth-muscle cell.