. Author manuscript; available in PMC: 2013 Feb 10.

Published in final edited form as: J Autoimmun. 2011 Dec 16;39(1-2):34–42. doi: 10.1016/j.jaut.2011.11.005

Table 4.

Proposed genetic factors involved in the etiology of PBC and SS. Data are gathered from HLA studies and genome-wide association studies (GWAS) along with the more recent epigenetic data.

	PBC	SS
HLA	DR3, DR8, and DR4 in white, DR2 and DR3 in Japanese, DQA10102, and DQ/β10402	DR2, DR3
GWAS	DQB1, IL12A, IL12RB2, STAT4, IRF5, IKZF3/ORMDL3, SPIB	STAT4, IRF5
Epigenetics	different methylation in hemidesmosome gene; disease-specific miRNAs in minor salivary glands	different methylation at X-linked promoters