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PDK1 knockdown reduces PCa cell motility. (A) Wound healing assays for PC-3, DU145, and LNCaP cell lines at 0 and 12 hours with control siRNA (siCtrl) compared to siPDK1 (siPDK1-1 and siPDK1-2 for PC-3 and siPDK1-1 for DU145 and LNCaP). Dotted lines show areas used for quantification. Migration results are represented in B (from top to bottom: PC-3, DU145, and LNCaP) in terms of percentage recovery of initial surface area after wounding (hour).
