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. Author manuscript; available in PMC: 2013 Feb 11.
Published in final edited form as: Biochem Biophys Res Commun. 2011 Jul 22;412(1):160–164. doi: 10.1016/j.bbrc.2011.07.066

Fig. 4.

Fig. 4

Schematic model - The impaired bone anabolic effect of PTH in Fgf2 knockout mice is associated with reduced ATF4 expression. Anabolic action of PTH on bone formation requires FGF2 and FGF2 increases ATF4 expression and transcriptional activity in osteoblasts. Moreover, ATF4 is a downstream target of PTH signaling in osteoblasts and ATF4 is critical for osteoblasts differentiation. Therefore, attenuated ATF4 expression in Fgf2−/− mice by PTH injection may contribute to reduced osteoblasts differentiation characterized by decreased osteocalcin and type I collagen expression, which results in impaired stimulation of bone formation by PTH.