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Effect of perinatal nicotine exposure on acetylcholine tracheal constriction response in F1 and F2 offspring. Compared to the control group, with nicotine administration there was a significant increase in tracheal constriction in response to acetylcholine only in the males of both the F1 and F2 generations. Values are means ± SE; * P < 0.05, ** P < 0.01, versus control group; n = 5 to 6.
