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. Author manuscript; available in PMC: 2013 Feb 11.
Published in final edited form as: Transfusion. 2009 Oct 10;50(2):324–333. doi: 10.1111/j.1537-2995.2009.02438.x

Fig. 2.

Fig. 2

Previously undescribed mutations predicting amino acid substitutions in GPIIb or GPIIIa were identified in paternal DNA. The identified mutations were A to C at Nt 487 of GPIIIa Exon 3 predicting a lysine-to-glutamine substitution at Amino Acid 137 (Case 1, Sta), C to T at Nt 1949 of GPIIb Exon 20 predicting a threonine-to-methionine switch at Amino Acid 619 (Case 2, Kno), and G to A at Nt 1960 of GPIIIa Exon 11 predicting a glutamic acid-to-lysine switch at Amino Acid 628 (Case 3, Nos). Sequencing results for Case 1 (Sta) and Case 3 (Nos) are those obtained with forward primers; results shown for Case 2 (Kno) are those obtained with antisense primers. Locations of codons encoding the HPA-16 (Duv) and HPA-4 (Pen, Yuk) polymorphisms adjacent to the Sta mutation and the codon that encodes the HPA-11 polymorphism (Gro) adjacent to the Nos mutation are also shown. AA = amino acid.