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PTH and PTHrP bind and stimulate the same receptor to mediate divergent functions. PTH is rapidly secreted from the chief cells in parathyroid gland in response to small decreases in Ca2+ in the blood to restore a normal calcium level (≈1.2 mM) by promoting the release of calcium from bone and calcium reabsorption from the kidney. PTHrP is produced and secreted from many tissues and plays a critical role in tissue development, in particular the skeleton and mammary glands
