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. Author manuscript; available in PMC: 2013 Oct 9.
Published in final edited form as: J Chem Theory Comput. 2012 Mar 12;8(10):3769–3776. doi: 10.1021/ct300024z

Figure 1.

Figure 1

a) First-order propagated systematic error in free energy for M1, a model two-state system with constant energy errors (δE1 and δE2) at different relative energies. At relative energies greater than |2| kcal/mol the lower energy microstate dominates in the propagated error, but at smaller relative energies the total systematic error approaches the arithmetic mean systematic error of each microstate. b) First-order random error in free energy of the same two-state system. Random error is decreased as the energies of the two microstates approach one another.