Table 1:
Patient characteristics
| Patient characteristics | Most-undersized group | Best-matched group | Most-oversized group |
|---|---|---|---|
| Number of patients | 10 | 10 | 10 |
| Demographics | |||
| Recipient age (years) | 47.4 (14.5) | 44.0 (14.9) | 49.8 (15.2) |
| Hypertension | 4 (40%) | 0 (0%)*,*** | 4 (40%) |
| Diabetes mellitus | 3 (30%) | 1 (10%) | 3 (30%) |
| Coronary artery disease | 0 (0%) | 0 (0%) | 0 (0%) |
| Creatinine | 0.92 (0.4) | 0.83 (0.3) | 0.83 (0.2) |
| Body mass index | 26.8 (5.0) | 23.6 (4.9) | 24.3 (5.0) |
| In ICU prior to transplant | 5 (50%)** | 3 (30%)*** | 0 (0%)**,*** |
| Transplant indications | |||
| LAS Group A (obstructive disease) | 1 (10%) | 2 (20%) | 4 (40%) |
| LAS Group B (pulmonary vascular) | 1 (10%) | 1 (10%) | 0 (0%) |
| LAS Group C (cystic fibrosis) | 3 (30%) | 5 (50%) | 3 (30%) |
| LAS Group D (restrictive disease) | 5 (50%) | 2 (20%) | 3 (30%) |
| Lung allocation score, median (IQR) | 47.6 (42–75)*,** | 38.0 (34–41)* | 36.5 (33–41)** |
| Operative characteristics | |||
| Pulmonary artery systolic pressurea | 52.7 (29.4) | 45.1 (21.1) | 41.7 (8.7) |
| Ischaemic time (min) | |||
| Left, median (IQR) | 272 (198–320) | 260 (195–317) | 256 (206–320) |
| Right, median (IQR) | 241 (182–282) | 199 (159–252) | 192 (141–258) |
| Cardiopulmonary bypass | 7 (70%)*,** | 2 (20%)* | 2 (20%)** |
| PRBC utilization in unitsb | 1.5 (2.8) | 1 (1) | 0.4 (0.7) |
| Graft volume reduction | 0 (0%) | 0 (0%) | 1 (10%) |
| Induction therapy | 6 (60%) | 6 (60%) | 7 (70%) |
| Size-matching characteristics | |||
| Recipient | |||
| Recipient gender (female/male) | 6/4 | 6/4 | 4/6 |
| Recipient height (cm) | 170 (7.7)** | 170 (9.2)*** | 162 (4.9)**,*** |
| Recipient pTLC (l) | 6.1 (0.8)** | 6.2 (1.1)*** | 5.3 (0.6)**,*** |
| Donor | |||
| Donor age (years) | 46.0 (17)** | 45.6 (13)*** | 34.9 (9)**,*** |
| Donor smoking | 4 (40%) | 5 (50%) | 5 (50%) |
| Donor gender (female/male) | 8/2*,** | 4/6*,*** | 0/10**,*** |
| Donor height (cm) | 158 (9.3)*,** | 169 (9.5)*,*** | 173 (12)**,*** |
| Donor pTLC (l) | 4.9 (0.8)*,** | 6.1 (1.2)*,*** | 6.7 (0.9)**,*** |
| pTLC ratio (SD) | 0.80 (0.09)*,** | 0.99 (0.03)*,*** | 1.26 (0.10)**,*** |
aData available for 22 of 30 patients.
bData available for 23 of 30 patients.
*Significant (P < 0.05) difference between most-undersized and best-matched cohort.
**Significant (P < 0.05) difference between most-undersized and most-oversized cohort.
***Significant (P < 0.05) difference between most-oversized and best-matched cohort.
LAS: lung allocation scores; IQR: interquartile range; pTLC: predicted total lung capacity; ICU: intensive care unit; PRBC: packed red blood cells.