Fig. 1.

Characterization of natriuretic peptide receptor (NPR) transcript expression and heart weight-to-body weight phenotype in NPR-A−/− mice. A: expression of transcripts for NPR-A, NPR-B, and NPR-C in lung, and pulmonary microvascular endothelial cells (PMVEC) isolated from NPR-A wild-type (NPR-A+/+) and knockout mice (NPR-A−/−). B: heart weight-to-body weight ratio in NPR-A wild-type, heterozygote (NPR-A+/−), and knockout mice. Values are means ± SD; n = 12 per group. *P < 0.05 vs. NPR-A+/+.