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ANP attenuates agonist-induced pulmonary edema in NPR-A wild-type and knockout mice. Effect of ANP infusion on lung wet-to-dry weight ratios in NPR-A+/+ or NPR-A−/− mice treated with saline, TRAP, or LPS in the presence or absence of ANP is shown. Values are means ± SD; n = 5 per group, except for saline + ANP (n = 3). *P < 0.05 vs. TRAP + ANP. †P < 0.05 vs. LPS + ANP.
