Table 6.
Summarized results from stages 1 and 2 of the GWAS of overall survival from pancreatic cancer.
| Discovery | Validation | Combined | ||||
|---|---|---|---|---|---|---|
| SNP, Minor Allele, Chromosome, Genea |
HRb (95% CI) | P-valuec | HRd (95% CI) | P-valuec | HRd (95% CI) | P-valuec |
| rs1482426 G 12q21 - |
1.67 (1.16–2.41) | 3.6×10−5 | 1.73 (1.25–2.40) | 0.001 | 1.74 (1.38–2.18) | 1.7×10−6 |
| rs4285214 G 5q23 ZNF608 |
1.65 (1.35–2.02) | 7.9×10−7 | 1.09 (0.90–1.31) | 0.39 | 1.33 (1.16–1.53) | 4.1×10−5 |
| rs7849571 G 9p21 - |
1.63 (1.28–2.07) | 7.2×10−5 | 1.14 (0.90–1.43) | 0.27 | 1.35 (1.14–1.59) | 3.7×10−4 |
| rs11151040 T 18q23 - |
2.57 (1.61–4.10) | 7.6×10−5 | 1.27 (0.76–2.15) | 0.36 | 1.84 (1.30–2.61) | 5.6×10−4 |
| rs3747572 C 16p13 GLIS2 |
1.83 (1.39–2.40) | 1.3×10−5 | 1.10 (0.86–1.42) | 0.44 | 1.38 (1.15–1.66) | 6.2×10−4 |
| rs10189511 A 2q34 - |
2.11 (1.51–2.95) | 1.2×10−5 | 1.07 (0.77–1.48) | 0.70 | 1.50 (1.19–1.89) | 6.7×10−4 |
| rs1344963 T 12q21 - |
2.59 (1.69–3.97) | 1.4×10−5 | 1.18 (0.85–1.66) | 0.32 | 1.56 (1.20–2.03) | 8.5×10−4 |
| rs4903736 A 14q24 - |
1.59 (1.27–1.98) | 4.5×10−5 | 1.02 (0.78–1.32) | 0.90 | 1.33 (1.12–1.58) | 9.8×10−4 |
| rs11024097 T 11p15 PLEKHA7 |
1.54 (1.25–1.90) | 4.2×10−5 | 1.01 (0.81–1.26) | 0.91 | 1.28 (1.10–1.49) | 0.001 |
| rs4903741 C 14q24 - |
1.57 (1.25–1.96) | 8.7×10−5 | 1.04 (0.83–1.31) | 0.72 | 1.29 (1.10–1.52) | 0.002 |
| rs12835268 C Xp21 - |
1.50 (1.24–1.82) | 3.4×10−5 | 1.05 (0.86–1.28) | 0.64 | 1.23 (1.08–1.41) | 0.003 |
| rs16867625 T 8q22 - |
2.33 (1.55–3.51) | 5.0×10−5 | 1.15 (0.75–1.75) | 0.52 | 1.55 (1.16–2.08) | 0.003 |
| rs7016046 A 8q24 - |
1.83 (1.38–2.43) | 3.1×10−5 | 1.02 (0.76–1.38) | 0.89 | 1.36 (1.11–1.67) | 0.004 |
| rs2056096 T 18q12 - |
1.56 (1.20–2.03) | 7.3×10−5 | 0.97 (0.78–1.20) | 0.76 | 1.24 (1.07–1.44) | 0.005 |
| rs8034546 T 15q14 - |
1.62 (1.29–2.04) | 4.0×10−5 | 0.97 (0.75–1.26) | 0.85 | 1.27 (1.07–1.51) | 0.005 |
| rs1867348 T 6q25 IGF2R |
2.02 (1.43–2.85) | 6.3×10−5 | 0.98 (0.70–1.37) | 0.90 | 1.38 (1.08–1.75) | 0.009 |
| rs956518 G 4p15 - |
0.62 (0.50–0.79) | 5.7×10−5 | 1.13 (0.92–1.40) | 0.24 | 0.82 (0.70–0.95) | 0.01 |
| rs10167103 C 2q14 - |
1.53 (1.25–1.88) | 5.0×10−5 | 0.92 (0.76–1.13) | 0.43 | 1.20 (1.04–1.38) | 0.01 |
| rs38402 G 7p15 GGCT |
4.75 (2.19–10.31) | 8.2×10−5 | 1.25 (0.65–2.41) | 0.50 | 1.86 (1.13–3.05) | 0.01 |
| rs3795244 T 17q11 ZNF207 |
2.46 (1.69–3.58) | 3.0×10−6 | 0.89 (0.61–1.29) | 0.53 | 1.34 (1.03–1.74) | 0.03 |
| rs1944395 C 18q12 - |
1.50 (1.23–1.84) | 8.3×10−5 | 0.86 (0.70–1.06) | 0.16 | 1.16 (1.01–1.35) | 0.04 |
| rs1388193 T 13q31 - |
1.77 (1.34–2.34) | 6.5×10−5 | 0.72 (0.53–0.99) | 0.04 | 1.13 (0.92–1.38) | 0.25 |
a
closest RefSeq annotated gene within +/− 20kb;
b
univariate Cox proportional hazards model;
c
1-d.f. Wald test for significance;
d
Cox proportional hazards model adjusted for race;
Abbreviations: HR = per-allele hazard ratio; CI = confidence interval