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. 2013 Jan 4;19(5-6):685–696. doi: 10.1089/ten.tea.2012.0047

FIG. 1.

FIG. 1.

Bone mineral density (BMD) changes in the animals. Percent changes of BMD relative to baseline of each group (A) and BMD relative to the ovariectomy (OVX)-Vehicle group (B). Ten-week-old female nude mice were sham-operated (Sham-op) or OVX and randomized into six groups; Sham-op+Vehicle mice (n=8), OVX+Zoledronate (Zol) mice (n=8), OVX+human umbilical cord blood mesenchymal stem cell (hUCB-MSC)-conditioned medium (OVX+CM) mice (n=8), OVX+hUCB-MSCs (n=8), OVX+human dermal fibroblast (hDFB) (OVX+DFB), or OVX+Vehicle mice (n=8). The mice were injected with vehicle, hUCB-MSC CM, hUCB-MSCs, or hDFBs at days 1, 2, 8, and 9, and BMD (g/cm2) was measured with a PIXImus densitometer at 4-week intervals as indicated. For the OVX-Zol group, zoledronate (100 μg/kg) was given at days 1 and 8. Data are the means±standard deviation (SD). *p<0.01 versus OVX-Vehicle at 4 weeks, #p<0.01 versus OVX-Vehicle at 8 weeks.