Comparisons of circadian activity rhythm measures (amplitude, acrophase, mesor, up-mesor, down-mesor and F-statistic) between BC patients and controls over time (mean+SE). Smaller values of amplitude and F-statistic indicate disrupted circadian activity rhythm; later times of acrophase, up-mesor and down-mesor indicate delayed circadian activity rhythms. Baseline=before the start of chemotherapy, Cycle-4=at the end of cycle 4 of chemotherapy. Compared to controls at the same time point: * p<0.05, ** p<0.01, *** p<0.0001; compared to Baseline for the same group: † p<0.05, †† p<0.01, ††† p<0.0001.