Table 1.

Summary of Genetic Association Data for IL-17–Related Genes Involved in Psoriasis

Locus	Other Diseases	Pathways	IL-17 Relevance	References
IL23A		IL-23	Upstream	(Nair et al, 2009)
IL12B	IBD, PsA, AS, MS	IL-23	Upstream	(Cargill et al, 2007; Fisher et al, 2008; Nair et al, 2009; Nair et al, 2008; Parkes et al, 2007; Patsopoulos et al, 2011; Wellcome Trust Case Control et al, 2007; Zhang et al, 2009)
IL23R	IBD, PsA, AS, Behcet	IL-23	Upstream	(Cargill et al, 2007; Duerr et al, 2006; Filer et al, 2008; Jiang et al, 2010; Mizuki et al, 2010; Nair et al, 2009; Remmers et al, 2010; Wellcome Trust Case Control et al, 2007)
TYK2	IBD, SLE, MS?	IL-23	Upstream	(Australia and New Zealand Multiple Sclerosis Genetics Consortium, 2009; Ban et al, 2009; Franke et al, 2010; Sigurdsson et al, 2005; Strange et al, 2010)
TRAF3IP2	PsA	IL-17 and NF-κB	Downstream	(Ellinghaus et al, 2010; Huffmeier et al, 2009; Strange et al, 2010)
REL	PsA, RA, CeD	NF-κB	Up/Downstream	(Ellinghaus et al, 2012; Gregersen et al, 2009; Strange et al, 2010; Trynka et al, 2009)
NFKBIA	PsA	NF-κB	Up/Downstream	(Strange et al, 2010; Stuart et al, 2010)
TNFAIP3	PsA, SLE, RA, CeD	NF-κB	Up/Downstream	(Graham et al, 2008; Musone et al, 2008; Nair et al, 2009; Plenge et al, 2007; Strange et al, 2010; Thomson et al, 2007; Trynka et al, 2009)
TNIP1	PsA, SLE, SSc	NF-κB	Up/Downstream	(Allanore et al, 2011; Gateva et al, 2009; Nair et al, 2009; Strange et al, 2010)
DEFB4		IL-17 regulated gene	Downstream	(Hollox et al, 2008)

AS=ankylosing spondylitis; CeD=celiac disease; IBD=inflammatory bowel disease (including Crohn’s disease and ulcerative colitis); IL=interleukin; MS=multiple sclerosis; NF-κB=nuclear factor kappa B; PsA=psoriatic arthritis; RA=rheumatoid arthritis; SLE=systemic lupus erythematosus; SSc=systemic sclerosis