TABLE 1.
Published studies using the Gen-Probe MTD test with CSF for diagnosis of TBM
| Authors (reference) | Setting | MTD kit useda | No.
|
% MTD sensitivity (95% CI) | % MTD specificity (95% CI) | ||||
|---|---|---|---|---|---|---|---|---|---|
| CSF specimens | TBM CSF specimens | AFB in CSF | Positive cultures | MTD positive | |||||
| Chedore and Jamieson (5) | Canadian reference lab | II | 311 | 16 | 7 | 16 | 15 | 93b (70-100) | 99 (98-100) |
| Baker et al. (1) | U.S. inner city hospital | II | 29 | 9 | 0 | 5 | 5 | 56 (21-86) | 100 (86-100) |
| Lang et al. (13) | Dominican Republicc | I | 84 | 19 | 0 | 5 | 4 | 33 (17-55) | 100 (94-100) |
| Gamboa et al. (8) | Spanish hospital | I | 22 | 8 | 0 | 8 | 5 | 63 (26-90) | 100 (77-100) |
| Gamboa et al. (9) | Spanish hospital | I | 17 | 8 | 0 | 8 | 5 | 63 (26-90) | 100 (66-100) |
| Ehlers et al. (7) | German hospital | I | 51 | 6 | 1 | Not given | 4 | 67 (24-94) | 98 (87-100) |
| Pfyffer et al. (17) | Swiss hospital | I | 54 | 6 | 1 | 5 | 6 | 100 (54-100) | 96 (85-99) |
| Total | 568 | 72 | 9 | 47 | 44 | 61 (49-72) | 99 (98-100) | ||
a
I, original MTD kit; II, enhanced MTD.
b
No data on clinical diagnosis were given.
c
The assay was done in the United States with frozen CSF.