Fig. 1.
(a) The 24-h study: Brain edema detected in ipsilateral basal ganglia was significantly higher among ICH groups when compared with sham-operated animals (#p < 0.001 vs. sham, ANOVA). Geldanamycin (10 mg/kg) reduced the brain water content of ipsilaterally basal ganglia significantly (*p < 0.001 vs. vehicle, ANOVA). A low concentration of drug remains ineffective. (b) The 72-h study: Brain edema spread into other brain compartment of vehicle-treated mice compared with sham-operated animals (#p < 0.001 vs. sham, ANOVA). Geldanamycin (10 mg/kg) reduced brain water content significantly (*p < 0.001 vs. vehicle, ANOVA)