Figure 4. FF blocks ProRS.

Febrifugine (FF) docked to the active site of P. falcipaurm ProRS (UniProtKB code Q8I5R7). ProRS and FF are colored as cyan and yellow, respectively. The hydrogen bonds are indicated with dashes. The P. falciparum ProRS structure was generated by the protein structure homology-modeling sever SWISS-MODEL²⁰. FF was docked into the P. falciparum ProRS active site based on the structure of ProRS:halofuginone:ATP^a complex, while ATP was docked based on the structure of the T. thermophilus ProRS:tRNA:ATP complex (PDB code 1H4Q).