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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: J Med Chem. 2013 Jan 3;56(2):534–546. doi: 10.1021/jm301580n

Table 1.

Focused Pi group heterocyclic library (53-61).

graphic file with name nihms-432998-t0012.jpg
Compound SID graphic file with name nihms-432998-ig0013.jpg 3CLpro
IC50μM
53 117686897 graphic file with name nihms-432998-t0014.jpg 10
54 117686898 graphic file with name nihms-432998-t0015.jpg 5.5
55 117686909 graphic file with name nihms-432998-t0016.jpg Inactive
56 117686901 graphic file with name nihms-432998-t0017.jpg 45
57 117686900 graphic file with name nihms-432998-t0018.jpg Inactive
58 117686899 graphic file with name nihms-432998-t0019.jpg 16% (100 μM)
59 117686904 graphic file with name nihms-432998-t0020.jpg Inactive
60 117686905 graphic file with name nihms-432998-t0021.jpg 23% (100 μM)
61 117686906 graphic file with name nihms-432998-t0022.jpg 23% (100 μM)
#

IC50values are average of two independent runs using triplicate concentrations, ‘Inactive’ defined as %inhibition <15% at 100 μM, CV <0.3

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