Table 4.
Granulometric parameters of W/O/W nanoemulsions with gastric and intestinal pH-simulating aqueous solutions
| Formulation/observation time | pH 1.2 MDS (nm)a |
PDI (nm)a | pH 6.8 MDS (nm)a |
PDI (nm)a |
|---|---|---|---|---|
| A/T0 | 177.30 ± 3.06 | 0.106 ± 0.070 | 211.60 ± 6.56 | 0.133 ± 0.030 |
| A/T2 h | 201.90 ± 2.51 | 0.100 ± 0.023 | 230.30 ± 6.45 | 0.137 ± 0.019 |
| B/T0 | 49.72 ± 0.20 | 0.150 ± 0.022 | 47.27 ± 0.30 | 0.138 ± 0.012 |
| B/T2 h | 48.14 ± 0.31 | 0.108 ± 0.062 | 46,32 ± 0.31 | 0.112 ± 0.003 |
| C/T0 | 214.30 ± 0.37 | 0.352 ± 0.054 | 218.30 ± 1.51 | 0.319 ± 0.059 |
| C/T2 h | 210.90 ± 3.54 | 0.316 ± 0.042 | 213.40 ± 4.05 | 0.329 ± 0.072 |
Note:aData presented as mean value ± standard error (n = 3). A: Polysorbate-85/Labrasol®; B: Polysorbate-85/Cremophor® EL; C: glycerol/Polysorbate-85.
Abbreviations: MDS, mean droplet size; PDI, polydispersity index; W/O/W, water-in-oil-in-water.