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. 2012 Dec 5;109(4):1078–1090. doi: 10.1152/jn.00124.2012

Fig. 2.

Fig. 2.

Effect of TRPV1/TRPV1t inhibition on the NGCC-induced changes in the Bz-insensitive NaCl CT response. A: representative CT trace obtained while the wild-type (WT) mouse tongue was first stimulated with R and then with N, N+Bz, and N+Bz+2 μM NGCC maintained at room temperature with the stimulus series 1 protocol. Arrows represent time periods when the mouse tongues were superfused with R and the stimulating solutions. B: representative CT trace obtained while the WT mouse tongue was first stimulated with R and then with N+Bz+SB solutions containing NGCC (0.25–50 μM) maintained at room temperature with the stimulus series 2 protocol. C: representative CT trace in a TRPV1 knockout (KO) mouse while the mouse tongue was first stimulated with R and then with N, N+Bz, and N+Bz+2 μM NGCC maintained at room temperature with the stimulus series 1 protocol. Arrows represent time periods when the mouse tongues were superfused with R and the stimulating solutions. D: summary of the normalized CT responses to N+Bz, N+Bz+SB, and N+Bz+SB+2 μM NGCC in 3 WT mice and N+Bz and N+Bz+2 μM NGCC in 3 TRPV1 KO mice.