Fig. 7.

Low-voltage local stimulation significantly improves model thalamocortical (TC) cell relay. Spiking data from human recordings prior to, during, and after DBS were used as input for a model TC relay-cell subject to a periodic excitatory signal, and an error index was computed based on TC relay performance. Only local stimulation at therapeutic voltages produced a statistically significant decrease in the error index during stimulation relative to nonstimulation periods (***P < 0.001, repeated-measures ANOVA, Dunnett's post hoc test). Values are means + SE.