Table 1.

Correlation of chromosomal changes with clinical and histologic paramaters, and HPV status in CC patients

Characteristics	Amplification	Loss of 2q	Gain of 3q	Total losses (mean ± s.d.)	Total gains (mean ± s.d.)	Total changes (mean ± s.d.)
Histology
SCC (N = 72)	14	42	41	4.71 ± 3.64	3.93 ± 3.22	8.64 ± 6.31
AC (N = 5)	1	2	1	5.80 ± 3.63	3.20 ± 3.77	9.00 ± 7.11
Significance	p = 1.00	p = 0.65	p = 0.17	p = 0.52	p = 0.63	p = 0.90
Stage
I (N = 14)	1	8	6	5.00 ± 3.57	3.71 ± 2.95	8.71 ± 6.08
II (N = 18)	4	12	13	5.11 ± 3.80	3.94 ± 2.84	9.06 ± 6.16
III-IV (N = 45)	10	24	20	4.58 ± 3.65	3.91 ± 3.52	8.49 ± 6.57
Significance	p = 0.45	p = 0.63	p = 0.20	p = 0.85	p = 0.98	p = 0.95
Size of tumor
1–5 cm (N = 29)	6	20	15	5.62 ± 4.02	4.10 ± 3.26	9.72 ± 6.84
≥6 cm (N = 38)	6	18	20	4.18 ± 3.52	4.05 ± 3.48	8.24 ± 6.40
Significance	p = 0.60	p = 0.08	p = 0.94	p = 0.12	p = 0.95	p = 0.36
Age (yrs)
≤40 (N = 31)	8	21	16	4.58 ± 3.67	3.58 ± 2.67	8.16 ± 5.78
41–60 (N = 28)	5	12	13	5.39 ± 3.73	4.32 ± 3.37	9.71 ± 6.55
≥60 (N = 18)	2	11	13	4.17 ± 3.47	3.72 ± 3.95	7.89 ± 6.93
Significance	p = 0.44	p = 0.14	p = 0.13	p = 0.50	p = 0.67	p = 0.54
HPV type
HPV16 (N = 45)	7	27	26	4.62 ± 3.49	3.33 ± 2.85	7.96 ± 5.68
HPV18 (N = 4)	3	3	3	10.00 ± 5.48	8.75 ± 6.06	18.75 ± 11.53
Multiple (N = 10)	3	4	2	4.40 ± 2.37	4.10 ± 2.96	8.50 ± 4.74
Others (N = 16)	2	9	10	3.94 ± 3.00	3.81 ± 2.71	7.75 ± 5.11
Significance	p = 0.04	p = 0.11	p = 0.02	p = 0.01	p = 0.01
Treatment response
CR (N= 34)	5	21	21	4.91 ± 3.78	3.79 ± 3.46	8.71 ± 6.67
DOD/PR (N = 43)	10	23	21	4.67 ± 3.54	3.95 ± 3.08	8.63 ± 6.09
Significance	p = 0.35	p = 0.26	p = 0.78	p = 0.83	p = 0.96

P value corresponds to the P value from Chi-Square test, or from the Fisher's Exact test (where appropriate).