Table 1. Inhibition of tested proteases by compounds Camostat, “Novartis166” and “Novartis848”.

Protease	IC50 value/µM
	Camostat	Novartis166	Novartis848
h cationic trypsin	0.0028	0.008	0.003
h anionic trypsin	–	0.005	–
rat anionic trypsin S1-94	<0.0003	0.001	0.0001
h thrombin	0.458	39.3	20.5
h factor VIIa	0.531	>100	>100
h factor Xa	6.6	37.6	35.1
h factor XIa	0.008	17.1	0.61
h factor XIIa	8.0	43.0	>100
h plasma kallikrein	0.002	0.133	2.0
h kallikrein 1	72.4	18.8	4.48
h kallikrein 5	0.10	22.0	14.0
h kallikrein 7	41.5	>100	>100
h neutrophil elastase	91.4	48.6	>100
h pancreatic elastase	>50	>100	>100
rat pancreatic elastase		>100	-
h cathepsin G	44.6	61.0	54.6
h proteinase 3	>50	>100	>100
h chymotrypsin	12.17	2.26	59.3
h matriptase	0.0065	>30	>100
h chymase	>50	>100	>100
h cathepsin K	>50	>30	>100
h cathepsin L	>50	>30	>100
h cathepsin S	>50	>30	>100
h cathepsin C	>50	>30	>100
h cathepsin B	>50	-	>100