Table 1. Characteristics of the included studies.
| Author | Year | Country | Number of Patients | Duration of Follow-up | Staining patterns | Cutoff scores (high/low) | T category (T1,2/T3,4) | N category (Negative/ Positive) | Distant metastasis (M0/M1) | Histology (Well,mod/ Por) | Lymphatic Invasion (N/Y) | Vascular Invasion (N/Y) | 5-year OS rate | 5-year DFS rate |
| Kojima[39] | 2008 | Japan | 189 | Median 2024 days | membrane | >10% (21/168) | H(2/19) L(39/129) | H(9/12) L(91/77) | H(16/5) L(147/21) | H(21/0) L(139/29) | H(10/11) L(96/72) | H(2/19) L(40/128) | H 61.8%(13/21) L 81.3%(113/139) * | H 68.7%(11/16) L 78.5%(97/124)* |
| Wang[40] | 2009 | China | 73 | >3 years | membrane | >10% (38/35) | H(14/24) L(23/12) | NA | NA | H(22/16) L(22/13) | H(9/29) L(2/33) | NA | H 60.1%(23/38) L 91.6%(32/35) * | H 42.6%(16/38) L 91.2%(32/35)* |
| Li[41] | 2009 | China | 104 | 5 years | membrane | >5% (42/62) | NA | NA | NA | NA | NA | NA | H 45.2%(19/42) L 77.4%(48/62) | NA |
| Horst[42] | 2009 | Germany | 110 | median 7.9 years | membrane | >50% (36/74) | H(8/28) L(31/43) | NA | NA | H(36/0) L(74/0) | NA | NA | H 44.6%(16/36) L 74.3%(55/74)* | NA |
| Takahashi[43] | 2010 | Japan | 151 | Median 41 months | Membrane and cytoplasm | >50% (41/110) | H(12/29) L(26/84) | H(21/20) L(58/52) | H(30/11) L(84/26) | NA | H(11/30) L(27/83) | H(18/23) L(52/58) | H 45.5%(19/41) L 74.3%(82/110) | H 61.9%(19/30) L 76.7%(64/84) |
| Kojima(2) [44] | 2010 | Japan | 43 | NA | membrane | >10% (8/35) | H(3/5) L(18/17) | H(4/4) L(26/9) | NA | NA | H(4/4) L(22/13) | NA | H 72.5%(6/8) L 96.5%(34/35)* | H 22.8%(2/8) L 73.1%(26/35)* |
| Xi[45] | 2011 | China | 201 | >5 years | Membrane and cytoplasm | score ≥5 (110/91) | H(23/87) L(52/39) | H(53/57) L(75/16) | H(100/10) L(90/1) | H(101/9) L(76/15) | NA | NA | H 22.7%(25/110) L 82.4%(75/91) | NA |
| Choi[15] | 2009 | South Korea | 523 | NA | cytoplasm | >0% (128/395) | H(9/119) L(49/346) | H(56/72) L(178/217) | H(124/4) L(378/17) | H(100/28) L(316/79) | H(56/72) L(169/226) | H(126/2) L(387/8) | H 70.8%(90/128) L 68.0%(269/395)* | NA |
| Garcia[46] | 2010 | Spain | 45 | Median 40 months | membrane | >10% (17/28) | NA | NA | NA | NA | NA | NA | H 92.0%(15/17) L 64.0%(18/28)* | H 64.9%(11/17) L 34.1%(10/28)* |
| Nagata[47] | 2011 | Japan | 27 | NA | Membrane | >0% (16/11) | NA | NA | NA | NA | NA | NA | H 13.3%(2/16) L 20.0%(2/11) | NA |
| Zhang[48] | 2012 | China | 125 | Median 6.5 years | membrane | score ≥4 (45/80) | H(4/41) L(12/68) | H(18/27) L(43/37) | NA | H(41/4) L(75/5) | NA | NA | H 57.8%(26/45) L 75.0%(60/80) | NA |
| Li(2) [49] | 2012 | China | 200 | 1 to 155 months | membrane and cytoplasm | Scores ≥4 (84/116) | H(6/78) L(17/99) | H(35/49) L(78/38) | NA | H(58/26) L(96/20) | NA | NA | H 31.0% (26/84) L 94.8% (110/116) | NA |
| Coco[50] | 2012 | Italy | 137 | NA | membrane and cytoplasm | >5% (65/72) | H(19/46) L(10/62) | H(34/31) L(42/30) | NA | H(41/24) L(54/18) | NA | NA | H52%(34/65) L72.2%(52/72) * | H47.8%(31/65) L71.8%(52/72) * |
| Hongo[51] | 2012 | Japan | 303 | NA | membrane | >5% (140/163) | H(38/102) L(45/118) | H(94/46) L(106/57) | NA | H(137/3) L(156/7) | H(112/28) L(131/32) | H(49/91) L(77/86) | H85%(119/140) L96.3%(157/163) * | NA |
| Bonetti[52] | 2012 | Italy | 95 | Median 108 months | membrane and cytoplasm | >50% (19/76) | NA | NA | NA | NA | NA | H(11/8) L(68/8) | H47%(9/19) L91.8%(70/76) * | H36.6%(7/19) L85.3%(65/76) * |
H: high expression; L: low expression; NA:not available; *:data read by GetData Graph Digitizer.