Table 1. Main characteristics of studies included in the meta-analysis.
| First author | Year | Country | Ethnicity | SOC | Genotypes distribution case/control, N(%) | MAF case/control, N(%) | Subtype of ICVD (diagnostic methods) | Adjustment for confounders | HWE Y/N(P) | Score | Sample size (power) | ||
| CC | TC | TT | T | ||||||||||
| Ito | 2000 | Japan | Asian | PB | 177(78.3)/261(86.7) | 46(20.4)/38(12.6) | 3(1.3)/2(0.7) | 52(11.5)/42(7.0) | SVO, LAA and TIA (brain CT and/or MRI) | age and sex matched | Y(0.63) | 8 | 226/301 (70.8%) |
| Shimo-Nakanishi | 2004 | Japan | Asian | PB | 102(85.0)/154(87.0) | 18(15.0)/23(13.0) | 0(0.0)/0(0.0) | 18(7.5)/23(6.5) | SVO and LAA (brain CT and/or MRI) | age, sex and ethnicity matched | Y(0.36) | 9 | 120/177 (47.5%) |
| Kuroda | 2007 | Japan | Asian | PB | 851(80.7)/840(79.6) | 189(17.9)/198(18.8) | 15(1.4)/17(1.6) | 219(10.4)/232(11.0) | SVO,LAA, CE and SUE (brain CT and/or MRI) | age, sex and ethnicity matched | Y(0.18) | 9 | 1055/1055 (9.5%) |
| Khan | 2007 | UK | Caucasian | PB | - | - | - | - | SVO (brain CT and/or MRI) | age, sex and ethnicity matched | NE | 9 | 316/638 (19.21%) |
| Genius | 2008 | Germany | Caucasian | PB | 73(45.3)/62(45.6) | 66(41.0)/68(50.0) | 22(13.7)/6(4.4) | 110(34.2)/80(29.4) | SVO,LAA, CE, SUE and TIA (brain CT and/or MRI) | sex and ethnicity matched | N(0.02) | 8 | 161/136 (27.2%) |
| Niemiec | 2010 | Poland | Caucasian | PB | 35(50.0)/26(52.0) | 27(38.6)/18(36.0) | 8(11.4)/6(12.0) | 43(30.7)/30(30.0) | Total ICVD (neuroimaging) | age and sex matched | Y(0.31) | 8 | 70/50 (5.1%) |
SOC: source of controls; PB: population-based.
MAF: minor allele frequency.
HWE: Hardy-Weinberg equilibrium; Y: yes; N: no; NE: not estimate.
TIA: transient ischemic attack; ICVD: ischemic cerebrovascular disease.
SVO: small-vessel occlusion; LAA: large-artery atherosclerosis; CE: cardioembolism; SUE: stroke of undetermined etiology.
CT: computed tomography; MRI: magnetic resonance imaging.