Table 2. Comparisons of estimated NMSS total and domain scores¹ by study group.

	Study Group			F-test p-value	Pair-wise Comparison p-values3
	PD	C	HFS		PD vs C	PD vs HFS		HFS vs C
NMSS total score	37.9 (±2.6)	11.2 (±0.9)	18.0 (±2.1)	<0.0001	<0.0001	<0.0001		0.003
Domains
Cardiovascular domain	1.0 (±0.2)	0.3 (±0.1)	0.3 (±0.1)	<0.0001	<0.0001	0.001	0.884
Sleep/fatigue domain	8.2 (±0.8)	2.5 (±0.3)	4.3 (±0.7)	<0.0001	<0.0001	0.002	0.016
Mood domain	9.2 (±1.2)	1.9 (±0.3)	3.5 (±0.8)	<0.0001	<0.0001	0.001	0.064
Perceptual problems/hallucinations domain	1.0 (±0.2)	0.05 (±0.02)	0.1 (±0.1)	<0.0001	<0.0001	0.0003	0.642
Attention/memoryDomain	3.5 (±0.3)	1.9 (±0.2)	2.9 (±0.5)	0.0003	0.0002	0.536	0.091
Gastrointestinal domain	3.2 (±0.5)	0.2 (±0.1)	0.3 (±0.1)	<0.0001	<0.0001	<0.0001	0.924
Urinary domain	5.1 (±0.6)	1.8 (±0.3)	3.4 (±0.6)	<0.0001	<0.0001	0.158	0.016
Sexual function domain2	1.4 (±0.2)	0.8 (±0.1)	0.7 (±0.2)	0.003	0.010	0.028	0.953
Miscellaneous domain	5.1 (±0.6)	1.6 (±0.2)	2.0 (±0.4)	<0.0001	<0.0001	<0.0001	0.648

PD: Parkinson's disease patients; C: Healthy controls; HFS: Hemifacial spasm patients.

¹Estimated mean scores adjusted for age and sex (± standard error) using GLIM negative binomial model ²Estimated percentages adjusted for age, sex and presence of diabetes mellitus (± standard error) using logistic regression model.

³Tukey-Kramer adjusted p-values.