Table 4. Comparisons of PD patient group estimated NMSS scores¹ by H&Y stage.

	H&Y Stage Group			F-test p-value	Pair-wise Comparison p-values2
	A	B	C		A vs B			B vs C		A vs C
	1–1.5	2−2.5	3−5
	(n = 33)	(n = 121)	(n = 46)
NMSS Total	19.7 (±3.0)	37.7 (±2.8)	57.0 (±6.9)	<0.0001	0.0003			0.004		<0.0001
Domains
Cardiovascular domain	0.5 (±0.3)	0.9 (±0.2)	2.0 (±2.0)	0.071		0.347	0.051		0.040
Sleep/fatigue domain	3.8 (±0.7)	7.8 (±0.7)	12.8 (±2.0)	<0.0001		0.002	0.008		<0.0001
Mood domain	2.9 (±0.9)	9.3 (±1.4)	14.5 (±3.6)	0.001		0.004	0.126		<0.0001
Perceptual problems /Hallucinations domain	1.0 (±0.7)	0.7 (±0.2)	1.8 (±1.0)	0.340		0.934	0.192		0.449
Attention/memory domain	2.7 (±0.6)	3.5 (±0.4)	4.7 (±0.9)	0.204		0.345	0.536		0.091
Gastrointestinal domain	2.0 (±0.7)	2.9 (±0.5)	5.5 (±1.4)	0.041		0.374	0.031		0.003
Urinary domain	4.0 (±0.6)	5.4 (±0.6)	7.2 (±1.4)	0.162		0.254	0.166		0.106
Sexual function domain	0.7 (±0.2)	1.4 (±0.2)	1.2 (±0.2)	0.040		0.016	0.426		0.062
Miscellaneous domain	2.0 (±0.5)	5.5 (±0.7)	6.0 (±1.2)	0.002		0.003	0.722		0.0004

¹Estimated mean scores adjusted for age and sex (± standard error) using GLIM negative binomial model.

²Tukey-Kramer adjusted p-values.