Table 1.
Effect of rutin and L-NIL on plasma nitrite/nitrate and cyclic guanosine monophosphate production mediated by renal ischemia/reperfusion
| Group | Plasma cGMP, mean (SD) pmol/mL | Percent change | Plasma nitrite/nitrate, mean (SD) μmol/L | Percent change |
|---|---|---|---|---|
| Sham | 5.56 (0.09)*† | — | 5.6 (0.31)* | — |
| Sham+NP | 5.78 (0.09)*† | + 3.9 | 5.3 (0.83)* | −5.3 |
| NP+I/R | 9.73 (0.05)†‡ | + 75 | 13.21 (0.8)†‡ | + 135 |
| NP+L-NIL+I/R | 6.86 (0.10)*‡ | + 23 | 5.9 (0.61)* | + 5.3 |
| NP+rutin+I/R | 6.56 (0.10)*‡ | + 17 | 5.6 (0.46)* | — |
cGMP = cyclic guanosine monophosphate; I/R = ischemia/reperfusion; L-NIL = L-N6-(1-iminoethyl)lysine; NP = nephrectomy; SD = standard deviation.
*
p < 0.05 v. NP+I/R group.
†
p < 0.05 v. NP+L-NIL+I/R group; p < 0.05 v. NP+rutin+I/R group.
‡
p < 0.05 v. sham group; p < 0.05 v. sham+NP group.