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. Author manuscript; available in PMC: 2013 Feb 12.
Published in final edited form as: Mol Pharm. 2010 Jun 7;7(3):775–785. doi: 10.1021/mp9002865

Figure 3.

Figure 3

MAP3 NO-donor silica nanoparticles are cytotoxic to ovarian cells. (A) The MTT assay was used to screen the cytotoxicity of control MAP3 silica nanoparticles alone, S-MAP3 NO-donor silica nanoparticles (d = 90 ± 10 nm), or L-MAP3 NO donor-modified silica nanoparticles (d = 350 ± 50 nm) on a panel of ovarian cells. The cell lines tested include ovarian cancer patient cell lines: HeyA8, OVCAR-3, OVCAR-4, OVCAR-5, OVCAR-8, A2780, and SKOV-3; the genetically-engineered isogenic cell lines: immortalized normal ovarian cells T29 and T80 and their H-Ras(G12V)-transformed counterparts T29H and T80H. IC50 values and standard deviations were calculated from three independent experiments and the p-values were calculated for comparing T29 and T80 small versus large MAP3 NO-donor nanoparticle IC50 values.