Table 2.

IRR gene expression and malignant phenotype biological properties.

N	IRR gene families dependent on NFkB	Biological functions leading to malignant phenotype	Reference
1	MMPs and TIMPs	Digestion of basement membrane and ECM; invasion	Tobar et al. (2010)
2	Adhesion molecules and counter-receptors	Detachment; homing; organ/tissue tropism; metastatic pattern	Marcu et al. (2010)
3	Chemokines and their receptors	Migration; homing; metastatic patterns	Lu and Kang (2010)
4	Inducible enzymes (COX2; iNOS)	Extravasation, migration, angiogenesis	Wang and Dubois (2006)
5	Cytokines and their receptors	Local amplification of IRR, proliferation, and survival	DiDonato et al. (2012)
6	VEGFs and VEGFRs	Angiogenesis	Ono (2008)
7	Growth and survival factors	Proliferation; antiapoptosis	Langley and Fidler (2011)
8	Acute-phase proteins	IRR amplification; chemotaxis; repair; DAMPs	Hiratsuka et al. (2008)
9	SOCS	Negative regulation of IRR; antimetastatic	Strebovsky et al. (2012)
10	Nm23	Cytoskeletal regulation and organization	Liu et al. (2011)