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. 2012 Dec 11;5(1):7–9. doi: 10.1002/emmm.201202207

Figure 1. Contrasting cancer stem cell models.

Figure 1

  1. AML follows a hierarchical model in which more mature blasts lose stem cell capacity.
  2. B-ALL may follow a stochastic model by which most, if not all, cells within the tumor are able to transplant the disease in xenograft models, and there is no strict hierarchy.