Figure 4. Engraftment kinetics of purified B-ALL subpopulation as assessed by sequential bone marrow punctures.

Mice from all limiting dilution experiments were pooled, as the number of mice in each individual transplantation experiment was too low for the analysis. Data are mean percentage of engraftment with bars showing standard error of the mean.

• A,B. Engraftment kinetics of CD10^high and CD10^low cells after transplantation of 100 (n = 4) or 1000–2000 blasts (n ≥ 4).
• C,D. Engraftment kinetics of CD20^high and CD20^low cells after transplantation of 100–300 (n ≥ 8) or 500–3000 blasts (n ≥ 21).
• E,F. Engraftment kinetics of CD34^high and CD34^low cells after transplantation of 100 (n ≥ 6, last points n = 2 for CD34^high and n = 3 for CD34^low) or 1000 blasts (n ≥ 9).