Table 1.
Patient characteristics (NCI risk factor: age and white cell count, and molecular-/cytogenetics) and experiments done with the respective samples
| Patient ID | Presentation or relapse | Cytogenetics | Age at presentation | WCC (×109) | Experiments |
|---|---|---|---|---|---|
| High hyperdiploidy | |||||
| L754 | Presentation | High hyperdiploidy | 3 | 142.0 | 2 |
| L578 | Relapse | High hyperdiploidy | 6 | 4.1 | 1 |
| L812 | Presentation | High hyperdiploidy | 2 | 81.9 | 7 |
| L835 | Presentation | High hyperdiploidy | 4 | 5.8 | 2 |
| 4917 | Presentation | High hyperdiploidy | 9 | 13.4 | 3 |
| Miscellaneous | |||||
| L736 | Presentation | dic(9;20)(p13;q11) | 2 | 71.9 | 2 |
| L776 | Presentation | IGH2-CRLF2 | 4 | 50.8 | 2,7 |
| L784 | Presentation | dic(9;20)(p13;q11) | 18 | 52.2 | 1,6,8 |
| L787 | Presentation | Normala,b | 19 | 11.6 | 7 |
| L803 | Presentation | Other | 18 | 99.7 | 1 |
| L825 | Presentation | Normala,b | 14 | 122 | 3 |
| L831 | Presentation | Faila,b | 16 | 6.1 | 1,2 |
| L833 | Presentation | Othera | 14 | 162 | 2 |
| L858 | Presentation | Normala,b | 14 | 27.0 | 3 |
| t(4;11)(q21;q23) or other MLL rearrangements | |||||
| L826 | Presentation | t(4;11) | <1 | >50 | 3,8 |
| L876 | Presentation | t(4;11) | <1 | 258 | 3 |
| L727 | Presentation | t(11;19)(q23;p13.3)/MLL-ENL | 1 | 94 | 2 |
| t(9;22)(q34;q11) and BCR-ABL1-like | |||||
| L4945 | Presentation | t(9;22) | 7 | 82 | 2 |
| L4951 | Presentation | t(9;22) | 15 | 184 | 1,2,3,5,6,8 |
| L4967 | Presentation | t(9;22) | 13 | 230 | 2,3 |
| L49101 | Presentation | t(9;22) | 3 | 55.9 | 1,2,3,8 |
| L49120 | Presentation | t(9;22) | 16 | 66.2 | 1,3 |
| 2003 | Presentation | t(9;22) | 15 | 179 | 3 |
| 2510 | Presentation | t(9;22) | 16 | 44.2 | 1,2,5,8 |
| 4540a | Presentation | t(9;22) | 2 | 71.0 | 6 |
| 8849 | Presentation | t(9;22) | 20 | 360 | 1 |
| EMCR1 | Presentation | BCR-ABL1-like | 4 | 264 | 1,2,3,4,5,6,8 |
| EMCR2 | Presentation | BCR-ABL1-like | 5 | 97.5 | 1,2,3 |
Symbols used for additional molecular diagnostics are:
a
no ETV6-RUNX1, no BCR-ABL1 and no MLL rearrangement;
b
no IZKF deletion.
The codes for the experiments are:
1:transplantation of blasts sorted for CD10; 2: transplantation of blasts sorted for CD20; 3: transplantation at limiting dilution with unsorted cells; 4: CD10 limiting dilution; 5: CD20 limiting dilution; 6: CD34 limiting dilution; 7: expression arrays with cells sorted for CD34; 8: TERT expression in blasts sorted for CD34.