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. 2012 Nov 25;5(1):105–121. doi: 10.1002/emmm.201201283

Figure 4. FTY720 inhibits A549-derived xenograft tumour growth in SCID mice.

Figure 4

  1. Effects of FTY720 (3 mg/kg/day via oral gavage for 15 days) on A549-derived xenograft tumour growth was evaluated in Balb/c SCID mice (n = 12). Tumour sizes were measured at every 2–3 days.
  2. PP2A (total), P-PP2A (inactive) and cMyc (total) were detected by IHC in tumour tissues obtained from mice treated with FTY720 compared to vehicle-treated controls.
  3. Electron microscopy of control and FTY720 treated tumours. Arrows indicate areas of mitochondria damage and cytoplasmic swelling.
  4. FTY720 and P-FTY720 were measured by LC/MS/MS in tumour and serum samples obtained from mice treated with FTY720 compared to vehicle treated controls. Error bars show s.d. (*p < 0.05, **p < 0.01).