Table 1.
Baseline (BL) demographics, observation period, Kellgren and Lawrence grades (KLG), and joint-space narrowing scores (JSN) in the medial femorotibial compartment (MFTC) for the coronal FLASH sample, the sagittal DESS sample, and the entire OAI progression cohort as reference.
| FLASH sample | DESS sample (12M) | DESS sample (24M) | OAI Progression Cohort | ||
|---|---|---|---|---|---|
| N | 445 | 375 | 522 | 1390 | |
| Gender | Women (%) | 281 (63.1%) | 209 (55.7%) | 300 (57.5%) | 793 (57.1%) |
| Men (%) | 164 (36.9%) | 166 (44.3%) | 222 (42.5%) | 597 (42.9%) | |
| Side | Left (%) | 2 (0.4%) | 186 (49.6%) | 261 (50.0%) | |
| Right (%) | 443 (99.6%) | 189 (50.4%) | 261 (50.0%) | ||
| Age (years) | Average | 63.2 | 61.0 | 61.2 | 61.4 |
| SD | 9.4 | 8.9 | 8.8 | 9.1 | |
| BMI (kg/m^2) | Average | 30.1 | 30.2 | 30.3 | 30.2 |
| SD | 4.7 | 5.1 | 5.0 | 4.9 | |
| Height (cm) | Average | 167.3 | 168.6 | 168.7 | 168.7 |
| SD | 8.8 | 9.0 | 9.2 | 9.3 | |
| Weight (kg) | Average | 84.6 | 86.1 | 86.3 | 86.2 |
| SD | 16.0 | 16.1 | 16.0 | 16.3 | |
| KLG | 0 | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 275.0 (21.5%) |
| 1 | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 173.0 (13.5%) | |
| 2 | 255 (57.3%) | 182 (48.5%) | 256 (49.0%) | 479.0 (37.5%) | |
| 3 | 135 (30.3) | 188 (50.1%) | 261 (50.0%) | 357.0 (27.9%) | |
| 4 | 55 (12.4%) | 5 (1.3%) | 5 (1.0%) | 106.0 (8.3%) | |
| medial JSN | 0 | 150 (33.7%) | 130 (34.7%) | 181 (34.7%) | 707.0 (55.3%) |
| 1 | 154 (34.6%) | 101 (26.9%) | 140 (26.8%) | 346.0 (27.1%) | |
| 2 | 102 (22.9%) | 141 (37.6%) | 198 (37.9%) | 266.0 (20.8%) | |
| 3 | 39 (8.8%) | 3 (0.8%) | 3 (0.6%) | 71 (5.6%) | |
| BL mJSW (mm) | Average | 3.7 | 3.9 | 3.9 | 4.0 |
| SD | 1.6 | 1.5 | 1.5 | 1.5 | |
| BL ThC (mm) | Average | 3.3 | 3.4 | 3.4 | N/A |
| SD | 0.8 | 0.7 | 0.7 | N/A |
All knees in the FLASH and the DESS sample had definite radiographic OA at baseline (BL), defined as Kellgren and Lawrence grade (KLG) >= 2 (obtained from central readings). SD = standard deviation. BMI = Body Mass Index. mJSW = minimum joint space width, ThC = Thickness of cartilage. 12M = 12 months follow-up, 24M = 24 months follow-up.
Height measurements were missing for ten participants from the FLASH sample and for ten participants from the DESS sample. Weight and BMI measurements were missing for one participant from the FLASH sample and for one participant from the DESS sample. FFR = fixed-flexion radiography