Table 2.
Mean change (MC in %), standard deviation (SD in %) of the change and responsiveness (sensitivity to change; SRM = standardized response mean) in cartilage thickness (ThCtAB) and medial joint space width (JSW) in the coronal FLASH sample (n=445 knees) over 12 months.
| All knees | KLG 2 | KLG 3 | KLG 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MC % | SD % | SRM | MC % | SD % | SRM | MC % | SD % | SRM | MC % | SD % | SRM | |
| MFTC | −1.1 | 3.9 | −0.28 | −0.6 | 3.2 | −0.18 | −1.9 | 4.7 | −0.41 | −1.9 | 5.6 | −0.34 |
| eMFTC | −1.4 | 6.5 | −0.22 | −0.8 | 4.6 | −0.17 | −2.7 | 9.1 | −0.30 | −2.5 | 11.2 | −0.22 |
| cMFTC | −1.6 | 5.0 | −0.32 | −0.9 | 4.3 | −0.22 | −2.7 | 5.6 | −0.49 | −2.8 | 8.2 | −0.34 |
| iMFTC | −0.7 | 3.4 | −0.22 | −0.3 | 2.9 | −0.11 | −1.3 | 3.7 | −0.35 | −1.5 | 5.0 | −0.30 |
| MT | −0.7 | 3.4 | −0.21 | −0.2 | 2.9 | −0.07 | −1.5 | 4.0 | −0.37 | −1.5 | 4.4 | −0.35 |
| cMF | −1.5 | 5.7 | −0.26 | −0.9 | 4.8 | −0.20 | −2.5 | 6.9 | −0.36 | −2.3 | 8.8 | −0.26 |
| eMT | −1.6 | 7.2 | −0.23 | −0.9 | 4.7 | −0.19 | −3.1 | 10.6 | −0.30 | −2.8 | 14.8 | −0.19 |
| cMT | −1.2 | 4.9 | −0.23 | −0.3 | 4.1 | −0.09 | −2.4 | 5.2 | −0.46 | −2.4 | 8.1 | −0.29 |
| iMT | −0.5 | 4.0 | −0.12 | −0.2 | 3.7 | −0.05 | −0.7 | 4.1 | −0.18 | −1.3 | 4.9 | −0.27 |
| aMT | −0.1 | 5.0 | −0.02 | 0.5 | 4.5 | 0.11 | −0.9 | 5.3 | −0.17 | −0.9 | 6.2 | −0.15 |
| pMT | −0.6 | 4.4 | −0.13 | −0.4 | 4.1 | −0.10 | −0.7 | 4.5 | −0.17 | −1.0 | 5.7 | −0.17 |
| ecMF | −1.3 | 8.1 | −0.16 | −0.7 | 6.4 | −0.11 | −2.3 | 10.4 | −0.22 | −2.1 | 13.0 | −0.16 |
| ccMF | −2.1 | 7.6 | −0.28 | −1.6 | 6.7 | −0.23 | −3.2 | 8.5 | −0.38 | −3.5 | 12.3 | −0.28 |
| icMF | −1.0 | 5.0 | −0.20 | −0.5 | 3.9 | −0.12 | −1.9 | 5.9 | −0.32 | −1.7 | 7.8 | −0.22 |
| mJSW | −2.3 | 15.2 | −0.15 | −1.9 | 14.1 | −0.13 | −4.2 | 16.0 | −0.26 | 0.3 | 21.2 | 0.02 |
| JSW(x=0.150) | −2.0 | 14.2 | −0.14 | −1.7 | 12.8 | −0.13 | −3.1 | 15.3 | −0.20 | −1.0 | 22.5 | −0.04 |
| JSW(x=0.175) | −2.1 | 13.2 | −0.16 | −1.7 | 11.7 | −0.14 | −3.5 | 14.5 | −0.24 | −0.6 | 22.2 | −0.03 |
| JSW(x=0.200) | −2.3 | 12.9 | −0.18 | −1.8 | 11.4 | −0.16 | −3.9 | 14.7 | −0.27 | −0.7 | 21.0 | −0.03 |
| JSW(x=0.225) | −2.3 | 11.7 | −0.20 | −1.9 | 10.4 | −0.18 | −3.5 | 12.6 | −0.28 | −1.9 | 21.0 | −0.09 |
| JSW(x=0.250) | −2.2 | 10.3 | −0.22 | −1.9 | 9.1 | −0.21 | −2.8 | 11.4 | −0.24 | −2.7 | 16.4 | −0.17 |
| JSW(x=0.275) | −1.8 | 9.8 | −0.19 | −1.5 | 8.6 | −0.17 | −1.8 | 11.1 | −0.17 | −4.6 | 14.9 | −0.31 |
| JSW(x=0.300) | −1.0 | 9.9 | −0.10 | −0.8 | 8.9 | −0.09 | −0.6 | 10.7 | −0.05 | −3.4 | 14.6 | −0.23 |
All knees had definite radiographic OA, defined as Kellgren and Lawrence grade (KLG) >= 2 (obtained from central readings; KLG 2: n=255, KLG 3: n=135, KLG 4: n=55). e/c/iMFTC = external/central/internal subregion of the medial femorotibial compartment; MT = medial tibia; a/pMT anterior/posterior subregion of the medial tibia; cMF = central, weight-bearing part of the medial femoral condyle; mJSW = minimal joint space width, JSW(X) = joint space width at fixed location measures in the medial femorotibial compartment (0.15 – 0.3).