Table 2.
Effect of nor-Bile Acids on Fluid Secretion in IBDUs using HCO3− - Containing and HCO3−-Free Buffer
Variable | % Increase in Luminal Area after 30 Minutes |
n | P value |
---|---|---|---|
HCO3 buffer | |||
Control | 12 ± 5 | 9 | |
UDCA 250 µM | 42 ± 13 | 9 | <0.001* |
norUDCA 250 µM | 65 ± 21 | 33 | <0.001* |
<0.01‡ | |||
T-norUDCA 250 µM | 49 ± 18 | 18 | <0.001* |
<0.05† | |||
NS‡ | |||
dinorUDCA 250 µM | 29 ± 12 | 18 | <0.01* |
<0.001† | |||
<0.05‡ | |||
HCO3−-free HEPES buffer | |||
Control | 15 ± 5 | 8 | |
norUDCA 250 µM | 31 ± 11 | 10 | <0.01* |
T-norUDCA 250 µM | 33 ± 7 | 8 | <0.01* |
NS† | |||
dinorUDCA 250 µM | 21 ± 12 | 8 | NS* |
NS† |
Values are expressed as the mean ± standard deviation.
Abbreviations: HEPES, 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid; NS, not significant.
P < 0.05 versus control.
P < 0.05 versus norUDCA 250 µM.
P < 0.05 versus UDCA 250 µM.