Table 1.

Prospective Lyme vaccine antigens from B. burgdorferi.

B. burgdorferi antigen	Mechanism of protection	How tested	Result	References
OspA	Antibody-mediated, transmission-blocking	Challenge of mice by injection, tissue transplant and tick transmission; challenge of monkeys by tick transmission	Efficacious, dependent upon antibody titer	Fikrig et al., 1990, 1992a,b; Probert and Lefebvre, 1994; Telford et al., 1995; Philipp et al., 1997
OspB	Antibody-mediated; elicits bactericidal antibodies	Active and passive protection against injection challenge	Potential for strain-dependent efficacy, due to truncations of OspB proteins in some strains	Fikrig et al., 1993; Telford et al., 1993; Coleman et al., 1994; Probert and Lefebvre, 1994; Probert et al., 1997
OspC	Antibody-mediated, within host	Challenge of mice by injection and tick transmission	Effective, but with minimal cross-species protection; failure to elicit long-term (anamnestic) response	Probert and Lefebvre, 1994; Gilmore et al., 1996, 2003; Probert et al., 1997
DbpA	Antibody-mediated, within host	Challenge of mice by injection and tick transmission	Protective against injected, but not tick-transmitted infection	Hanson et al., 1998; Hagman et al., 2000
Bbk32 (p35)	Antibody-mediated, within tick	Passive immunization against injection and tick challenge	Efficacy in combination with DbpA and OspC against challenge by injection but not singly	Fikrig et al., 1997, 2000; Brown et al., 2005