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Positive and negative characteristics of the OspA vaccine.
| PROs | CONs |
|---|---|
| Blocks transmission; easier to test for efficacy | Required maintenance of high antibody titers for efficacy (multiple boosts) |
| Subunit; does not interfere with immunodiagnosis | Some adverse reactions, potential for inducing autoimmunity |
| Targets a reasonably conserved protein within species | Not effective against other tick-borne diseases |
