Table 3.
Important miRNAs frequently altered in oral cancer†.
| miRNA | Regulation | Malignancy | Sample type | Method | Ref. |
|---|---|---|---|---|---|
| let-7a/7b | Down | OSCC | Cell lines | qRT-PCR | [102] |
| miR-16 | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-17-5p | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-21 | Up | Leukoplakia | Tissue | TaqMan® low density arrays, qRT-PCR | [96] |
| miR-24 | Up | TSCC | Tissue | qRT-PCR | [93] |
| miR-26a/b | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [91,98] |
| miR-29a | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-30a-3p | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-31 | Up | OSCC | Plasma | qRT-PCR | [103] |
| miR-34b/c | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-99a | Down | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-104 | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-107 | Down | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-124a | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-124b | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-125a/b | Down | OSCC | Saliva | qRT-PCR | [98,105] |
| miR-128a | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-132 | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-133a/b | Down | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-134 | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-137 | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-143 | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-145 | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-148b | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-149 | Down | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-155 | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-181b | Up | Leukoplakia | Tissue | TaqMan® low density arrays, qRT-PCR | [96] |
| miR-181c | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-194 | Down | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-195 | Down | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-198 | Up | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-200a | Down | OSCC | Saliva | qRT-PCR | [105] |
| miR-200b | Up | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-203 | Down | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-219 | Down | TSCC | Tissue | qRT-PCR (TaqMan® miRNA assay, 156miRNAs) | [91] |
| miR-221 | Up | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
| miR-345 | Up | Leukoplakia | Tissue | TaqMan® low density arrays, qRT-PCR | [96] |
| miR-375 | Down | OSCC | Tissue | qRT-PCR (TaqMan® miRNA assay) | [106] |
| miR-762 | Up | OSCC | Hamster cheek pouch | Microarray, qRT-PCR | [98] |
†
For a more comprehensive list, please refer to Supplementary Table 2.
OSCC: Oral squamous cell carcinoma; qRT-PCR: Quantitative reverse transcriptase PCR; TSCC: Tongue squamous cell carcinoma.