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Adverse events during sorafenib therapy.
| Adverse event* | All grades (%) | Grades 3-4 (%) |
|---|---|---|
| Fatigue | 68 | 12 |
| Anorexia | 47 | 7 |
| Diarrhoea | 42 | 11 |
| Rash | 33 | 4 |
| Nausea | 32 | 3 |
| Hand-foot syndrome | 26 | 12 |
| Hypertension | 18 | 3 |
| Vomiting | 16 | 3 |
| Thrombocytopenia | 5 | 3 |
| Bone marrow suppression | 4 | — |
| Metabolic/laboratory | 4 | 1 |
| Haemorrhage | 4 | — |
*Adverse events based on information in medical records and graded according to NCI-CTCAE v3.0.
