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(a, b) There are 2 elements with complementarity to the miR-200b seed region. (c) Luciferase reporter assays indicated that miR-200b regulates tissue inhibitor of metalloproteinase 2 (TIMP2) expression by targeting the 3’UTR, while miR-200a and negative (NC) could not. (d) The miR-200 family can be grouped into two subfamilies according to their function: mir-200b, mir-200c and mir-429/mir-200a and mir-141.
