Table 1.
Pathological Classification of 14,867 Thyroidectomies Performed at the Johns Hopkins Hospital Between May 1889 and October 2012
| Diagnosis | n | % |
|---|---|---|
| Developmental lesions (n=627) | ||
| Thyroglossal duct cyst | 598 | 4.0 |
| Aberrant thyroid | 16 | 0.1 |
| Congenital goiter | 13 | 0.1 |
| Inflammatory lesions (n=312) | ||
| Acute thyroiditis | 4 | 0.03 |
| Subacute thyroiditis | 18 | 0.1 |
| Granulomatous thyroiditis | 13 | 0.1 |
| Chronic infectious thyroiditis | 8 | 0.1 |
| Atrophy, scarring, or fibrosis | 59 | 0.4 |
| Amyloidosis of the thyroid | 3 | 0.02 |
| Chronic nonspecific lymphocytic thyroiditis | 207 | 1.4 |
| Nonautoimmune goiter (n=4998) | ||
| Simple colloid goiter (diffuse nontoxic goiter) | 1027 | 6.9 |
| Adenomatoid hyperplasia (multinodular goiter) | 3216 | 21.6 |
| oncocytic adenomatoid hyperplasia | 64 | 0.4 |
| with lymphocytic infiltration | 343 | 2.3 |
| with Hashimoto's thyroiditis | 94 | 0.6 |
| Thyroid cyst | 254 | 1.7 |
| Autoimmune thyroid diseases (n=1511) | ||
| Graves' disease | 1024 | 6.9 |
| Hashimoto's thyroiditis (isolated) | 462 | 3.1 |
| Riedel's thyroiditis | 25 | 0.2 |
| Hyperplasia (n=472) | ||
| Follicular hyperplasia | 409 | 2.8 |
| with lymphocytic infiltration | 38 | 0.3 |
| C-cell hyperplasia | 25 | 0.2 |
| Benign tumors (n=2927) | ||
| Adenoma, not otherwise categorized | 640 | 4.3 |
| Colloid adenoma | 929 | 6.3 |
| Follicular adenoma | 519 | 3.5 |
| with lymphocytic infiltration | 82 | 0.6 |
| with Hashimoto's thyroiditis | 27 | 0.2 |
| Hürthle cell adenoma | 340 | 2.3 |
| with lymphocytic infiltration | 15 | 0.1 |
| with Hashimoto's thyroiditis | 19 | 0.1 |
| Cystic adenoma | 57 | 0.4 |
| Fetal adenoma | 71 | 0.5 |
| Mixed adenoma | 162 | 1.1 |
| Papillary adenoma | 52 | 0.3 |
| Parathyroid adenoma | ||
| with Hashimoto's thyroiditis | 14 | 0.1 |
| Malignant tumors (n=3591) | ||
| Carcinoma, not otherwise categorized | 72 | 0.5 |
| Papillary carcinoma (n=2972) | 2233 | 15 |
| with lymphocytic infiltration | 508 | 3.4 |
| with Hashimoto's thyroiditis | 231 | 1.6 |
| Follicular carcinoma (n=162) | 145 | 1.0 |
| with lymphocytic infiltration | 12 | 0.1 |
| with Hashimoto's thyroiditis | 5 | 0.03 |
| Hürthle cell carcinoma (n=98) | 84 | 0.6 |
| with lymphocytic infiltration | 8 | 0.1 |
| with Hashimoto's thyroiditis | 6 | 0.04 |
| Medullary carcinoma (no.=160) | 138 | 0.9 |
| with lymphocytic infiltration | 13 | 0.1 |
| with Hashimoto's thyroiditis | 9 | 0.06 |
| Anaplastic carcinoma (n=59) | 55 | 0.4 |
| with lymphocytic infiltration | 4 | 0.03 |
| Lymphoma of the thyroid | 28 | 0.2 |
| Sarcoma of the thyroid | 4 | 0.03 |
| Metastasis to the thyroid | 28 | 0.2 |
| Paraganglioma of the thyroid | 2 | 0.01 |
| Teratoma of the thyroid | 2 | 0.01 |
| Langerhans cell histiocytosis | 1 | 0.01 |
| Solitary fibrous tumor (spindle cell tumor) | 1 | 0.01 |
| Castle diseasea | 1 | 0.01 |
| Insular carcinoma | 1 | 0.01 |
| Unknown pathological diagnosis | 188 | 1.3 |
| Normal thyroid tissue | 241 | 1.6 |
| Total | 14,867 | 100 |
a
Castle disease is a neoplasm that arises from ectopic intrathyroidal thymic tissue, or from intrathyroidal branchial pouch remnants.