Table 1. Study Results.

Variable	On/Off	Mean (±SD)	95% CI	z1	Probability >|z|
MoCA (total)	Off	19.95 (5.56)	16.8–23.2
	On	20.0 (4.50)	17.4–22.6	0.531	0.595
Dynamic Gait Index (total)	Off	14.4 (7.01)	9.38–19.42
	On	17.5 (6.94	12.53–22.47	2.045	0.0412
Berg Balance Scale (total)	Off	40.9 (9.67)	33.99–47.81
	On	46.5 (6.06)	42.17–50.83	2.68	0.0072
Jebsen Hand Test (total) (non-dominant)	Off	193.1 (111.6)	113.2–272.9
	On	217.3 (111.3)	137.7–296.9	1.070	0.285
Jebsen Hand Test (total) (dominant)	Off	131.2 (73.3)	78.8–183.6
	On	125.0 (57.1)	84.1–165.8	−0.459	0.647
Timed 25-foot Walk (average, two trials)	Off	8.5 (3.6)	5.9–11.1
	On	8.1 (2.1)	6.6–9.5	.0153	0.879
Beck Depression Inventory II (total)	Off	12.8 (9.7)	5.9–19.7
	On	10.4 (6.7)	5.6–15.2	−1.436	0.151
QuickDASH (disability/symptom score)	Off	43.2 (27.5)	23.5–62.8
	On	37.3 (26.5)	18.3–56.2	−1.02	0.307
UHDRS-1 Motor (total motor score)	Off	45.4 (10.4)	38.0–52.8
	On	36.1 (15.7)	24.9–47.3	−2.609	0.0092
UHDRS-1 Motor (max chorea)	Off	18.4 (2.5)	16.6–20.2
	On	10.8 (5.5)	6.9–14.7	−2.814	0.0052
UHDRS-1 Motor total motor – max chorea	Off	27.0 (9.9)	19.9–34.1
	On	25.3 (12.4)	16.5–34.1	−0.873	0.383
UHDRS-2 Cognition: Stroop Color-Word26	Off	7.72 (7.5)	.67–12.5
	On	14.3 (3.6)	11.5–17.1	2.191	0.0282
UHDRS-3 Behavior: Frequency and Severity	Off	9.3 (10.5)	4.5–22.3
	On	13.4 (12.5)	1.8–16.8	1.298	0.194
UHDRS-4 Functional Checklist	Off	15.2 (5.3)	11.4–19.0
	On	17.0 (5.0)	13.4–20.6	1.027	0.304
UHDRS-5 Independence Scale	Off	67.0(10.3)	59.6–74.4
	On	74.5(13.0)	65.2–83.8		0.0623

¹Wilcoxon matched-pairs signed-rank test.

²Statistically significant result.

³Two tailed paired Student's t-test.

Abbreviations: CI, confidence interval; MoCA, Montreal Cognitive Assessment; SD, standard deviation; UHDRS, Unified Huntington Disease Rating Scale.